Distúrbios cardiometabólicos em pessoas vivendo com HIV no interior da Amazônia, Brasil

Luiz Fernando Gouvea-e-Silva; Lívia Garcia Silva Sousa; Talys Francisco Modesto Filho; Maria Rita Ribeiro Aniceto; Silvania Yukiko Lins Takanashi; Marília Brasil Xavier

doi:10.46642/efd.v30i329.8365

Luiz Fernando Gouvea-e-Silva Universidade Federal de Jataí (UFJ) https://publons.com/researcher/AAJ-4119-2020 http://orcid.org/0000-0002-1953-9175
Lívia Garcia Silva Sousa Universidade Federal de Jataí (UFJ) https://publons.com/researcher/NBX-7697-2025 https://orcid.org/0000-0002-9712-5162
Talys Francisco Modesto Filho Universidade Federal de Jataí (UFJ) https://publons.com/researcher/NBX-7698-2025 https://orcid.org/0000-0002-7726-6769
Maria Rita Ribeiro Aniceto Universidade Federal de Jataí (UFJ) https://publons.com/researcher/NBX-8918-2025 https://orcid.org/0009-0006-2685-4575
Silvania Yukiko Lins Takanashi Universidade do Estado do Pará (UEPA) https://publons.com/researcher/AHB-7640-2022 https://orcid.org/0000-0002-6410-7160
Marília Brasil Xavier Universidade Federal do Pará (UFPA) https://www.scopus.com/authid/detail.uri?authorId=8585738500 https://orcid.org/0000-0003-2706-3880

DOI: https://doi.org/10.46642/efd.v30i329.8365

Abstract

Introduction: HIV infection, combined with antiretroviral therapy (ART), predisposes people living with HIV (PLHIV) to develop metabolic changes, changes in body fat distribution and increased cardiovascular risk (CVR). Objective: To analyze the relationship between metabolic syndrome (MetS), dyslipidemia, lipodystrophy, and CVR with the sociodemographic and clinical characteristics of PLHIV in the interior of the Amazon, Brazil. Methods: Cross-sectional study, composed of 115 PLHIV, treated at a Specialized Outpatient Clinic. Sociodemographic, clinical, laboratory, body composition information was sought, as well as the presence of MetS, dyslipidemia, lipodystrophy and CVR. Data were analyzed using descriptive and inferential statistics, adopting p<0.05. Results: Males predominated (59.1%), as well as dyslipidemia (81.7%). It was observed that 22.6% of PLHIV had MetS, 37.4% had lipodystrophy and 8.7% had moderate CVR. Age ≥40 years was associated with MetS and lipodystrophy; and longer duration of ART use was associated with lipodystrophy (p<0.05). Smoking and lipodystrophy were associated with moderate CVR (p<0.05). Altered values for abdominal circumference, glucose, LDL-c, HDL-c, body mass index and blood pressure were associated with MetS (p<0.05). Conclusion: According to the data, the high frequency of PLHIV with dyslipidemia, lipodystrophy and MetS is worrying, as is the relationship between MS and lipodystrophy and moderate CVR. Thus, the need for continuous monitoring and assertive interventions to prevent the onset or worsening of cardiometabolic diseases in this population is highlighted.

Keywords: HIV, Heart disease risk factors, Metabolic syndrome, Lipodystrophy, Dyslipidemias

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